I don’t read a lot of webcomics, and don’t follow any of them frequently, but there’s one that I do periodically revisit: Wondermark. I recommend it highly.
In keeping with the theme of my blog — all things book-related — I’ll occasionally post a funny book-related Wondermark comic. Here’s one about getting bothered while you’re trying to read. Don’t you hate that?
(Reminds me of that that funny music video I posted a while back.)